Motif ID: MEF2{A,B,C,D}.p2

Z-value: 2.288


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2BNB-MEF2Bchr19_-_193029160.581.1e-20Click!
MEF2Dchr1_-_1564603900.573.9e-20Click!
MEF2Bchr19_-_19281090,
chr19_-_19281062		0.433.6e-11Click!
MEF2Cchr5_-_881998680.371.2e-08Click!
MEF2Achr15_+_1001062140.305.9e-06Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_88450601 85.166 NM_001128310
NM_004684
 SPARCL1

SPARC-like 1 (hevin)

chr9_+_139871954 52.106 NM_000954
 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr5_-_42811959 48.647 NM_001085486
NM_001093726
NM_005410
 SEPP1


selenoprotein P, plasma, 1


chr13_-_45048436 47.509 NM_001243798
 TSC22D1
TSC22 domain family, member 1
chr9_+_139872014 47.143 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr12_+_52445185 45.517 NM_002135
NM_173157
 NR4A1

nuclear receptor subfamily 4, group A, member 1

chr12_-_45269340 43.145 NM_001145109
 NELL2
NEL-like 2 (chicken)
chr12_-_9268440 40.265 A2M
alpha-2-macroglobulin
chr12_-_16759939 39.524 NM_001243613
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_-_27472188 39.468 CLU
clusterin
chr14_-_21493858 38.581 NDRG2
NDRG family member 2
chr12_-_111358353 37.469 NM_000432
 MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr14_-_21493910 37.200 NM_016250
NM_201535
NM_201536
NM_201537
 NDRG2



NDRG family member 2



chr17_+_37821598 35.602 NM_003673
 TCAP
titin-cap (telethonin)
chr1_+_160085519 32.461 NM_000702
 ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr20_+_44657812 31.925 NM_020708
 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr2_-_211168315 31.864 NM_079422
 MYL1
myosin, light chain 1, alkali; skeletal, fast
chr20_+_44657858 31.810 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_92632608 31.456 NM_015237
 KIAA1107
KIAA1107
chr14_-_103989195 30.898 NM_001823
 CKB
creatine kinase, brain

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
6.50 4.10e-06 GO:0030049 muscle filament sliding
6.50 4.10e-06 GO:0033275 actin-myosin filament sliding
6.33 6.39e-06 GO:0070252 actin-mediated cell contraction
6.11 4.93e-02 GO:0030239 myofibril assembly
5.20 3.06e-03 GO:0006941 striated muscle contraction
4.72 6.16e-04 GO:0030048 actin filament-based movement
4.48 1.80e-02 GO:0031333 negative regulation of protein complex assembly
4.01 6.09e-03 GO:0051494 negative regulation of cytoskeleton organization
3.45 4.15e-08 GO:0003012 muscle system process
3.42 2.61e-02 GO:0034754 cellular hormone metabolic process
3.38 2.66e-03 GO:0045765 regulation of angiogenesis
3.35 1.16e-06 GO:0006936 muscle contraction
3.24 9.32e-03 GO:0007586 digestion
2.79 2.21e-04 GO:0007517 muscle organ development
2.67 1.43e-03 GO:0006874 cellular calcium ion homeostasis
2.59 2.92e-03 GO:0055074 calcium ion homeostasis
2.59 2.92e-03 GO:0072503 cellular divalent inorganic cation homeostasis
2.54 5.87e-05 GO:0061061 muscle structure development
2.49 6.42e-03 GO:0072507 divalent inorganic cation homeostasis
2.39 6.79e-04 GO:0055065 metal ion homeostasis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
8.91 7.64e-06 GO:0005859 muscle myosin complex
8.91 7.64e-06 GO:0032982 myosin filament
8.02 2.88e-05 GO:0016460 myosin II complex
4.42 1.14e-10 GO:0030016 myofibril
4.30 1.15e-10 GO:0043292 contractile fiber
4.26 1.84e-09 GO:0044449 contractile fiber part
4.09 2.74e-07 GO:0030017 sarcomere
3.76 2.12e-03 GO:0016459 myosin complex
3.12 3.94e-02 GO:0042383 sarcolemma
2.24 7.22e-13 GO:0005615 extracellular space
2.15 3.76e-15 GO:0044421 extracellular region part
2.02 1.33e-02 GO:0015629 actin cytoskeleton
1.87 2.03e-02 GO:0031012 extracellular matrix
1.75 6.00e-08 GO:0005887 integral to plasma membrane
1.74 5.16e-08 GO:0031226 intrinsic to plasma membrane
1.60 2.10e-09 GO:0005576 extracellular region
1.56 1.50e-02 GO:0005626 insoluble fraction
1.53 2.84e-03 GO:0000267 cell fraction
1.50 6.06e-07 GO:0044459 plasma membrane part
1.20 3.09e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
5.60 1.16e-05 GO:0008307 structural constituent of muscle
4.53 1.59e-03 GO:0008009 chemokine activity
4.40 9.69e-04 GO:0042379 chemokine receptor binding
3.88 2.35e-03 GO:0005319 lipid transporter activity
2.48 1.78e-03 GO:0005125 cytokine activity
2.33 3.36e-02 GO:0001664 G-protein-coupled receptor binding
1.56 3.96e-03 GO:0005102 receptor binding